Usually means: Chemical bond linking nucleotides together.
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We found 6 dictionaries that define the word phosphodiester:

General (3 matching dictionaries)
  1. phosphodiester: Wiktionary
  2. phosphodiester: Dictionary.com
  3. Phosphodiester: Wikipedia, the Free Encyclopedia

Medicine (3 matching dictionaries)
  1. phosphodiester: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)
  3. Phosphodiester: Medical dictionary

Definitions from Wiktionary (phosphodiester)

noun:  (biochemistry) any of many biologically active compounds in which two alcohols form ester bonds with phosphate
noun:  (biochemistry) any phospholipid, such as lecithin, that has two ester groups

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