Usually means: First identified case in outbreak.
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We found 6 dictionaries that define the word patient zero:

General (3 matching dictionaries)
  1. patient zero: Merriam-Webster
  2. patient zero: Wiktionary
  3. Patient Zero (The Outer Limits), Patient Zero (film), Patient Zero, Patient zero: Wikipedia, the Free Encyclopedia

Medicine (2 matching dictionaries)
  1. online medical dictionary (No longer online)
  2. Patient Zero: Medical dictionary

Slang (1 matching dictionary)
  1. Patient Zero: Urban Dictionary

Definitions from Wiktionary (patient zero)

noun:  (epidemiology) The initial patient in the population of an epidemiological investigation.
noun:  (figuratively, informal) The source or origin of something.

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