Usually means: Small, elevated, rounded skin lesion.
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We found 4 dictionaries that define the word papillule:

General (4 matching dictionaries)
  1. papillule: Merriam-Webster
  2. papillule: Collins English Dictionary
  3. papillule: Wordnik
  4. papillule: Wiktionary

Definitions from Wiktionary (papillule)

noun:  (zoology) A very small papilla.

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