Usually means: Suffering, distress, or intense discomfort.
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We found 17 dictionaries that define the word paine:

General (13 matching dictionaries)
  1. Paine: Merriam-Webster
  2. Paine: Collins English Dictionary
  3. Paine: Vocabulary.com
  4. Paine, paine: Wordnik
  5. Paine, paine: Wiktionary
  6. Paine: Webster's New World College Dictionary, 4th Ed.
  7. paine: Infoplease Dictionary
  8. paine: Dictionary.com
  9. Paine (Final Fantasy), Paine (Final Fantasy X-2), Paine (disambiguation), Paine (surname), Paine: Wikipedia, the Free Encyclopedia
  10. Paine: Rhymezone
  11. paine: FreeDictionary.org
  12. paine: Mnemonic Dictionary
  13. Paine: TheFreeDictionary.com

Business (1 matching dictionary)
  1. Paine: Legal dictionary

Computing (1 matching dictionary)
  1. Paine: Encyclopedia

Miscellaneous (1 matching dictionary)
  1. baby names list (No longer online)

Slang (1 matching dictionary)
  1. Paine: Urban Dictionary

(Note: See paines as well.)

Definitions from Wiktionary (Paine)

noun:  An English surname, of Norman derivation, meaning someone who lived outside of a city (see Latin pagus).
noun:  Obsolete spelling of pain. [(countable and uncountable) An ache or bodily suffering, or an instance of this; an unpleasant sensation, resulting from a derangement of functions, disease, or injury by violence; hurt.]

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