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We found 3 dictionaries that define the word original antigenic sin:

General (2 matching dictionaries)
  1. Original antigenic sin: Wikipedia, the Free Encyclopedia
  2. original antigenic sin: Wiktionary

Medicine (1 matching dictionary)
  1. original antigenic sin: Medical dictionary

Definitions from Wiktionary (original antigenic sin)

noun:  (immunology) The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections.

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