Usually means: Sole, unique, without any equal.
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We found 15 dictionaries that define the word one and only:

General (13 matching dictionaries)
  1. one and only: Longman Dictionary of Contemporary English
  2. the one and only: Merriam-Webster
  3. one and only: Oxford Learner's Dictionaries
  4. one and only: Collins English Dictionary
  5. one and only: Vocabulary.com
  6. one and only: Wiktionary
  7. one and only: Dictionary.com
  8. One and Only (Adele song), One and Only (album), One and only, The One and Only (Kirsty MacColl album), The One and Only (Lefty Frizzell album), The One and Only (Lil Wyte album), The One and Only (TV programme), The One and Only (TV series), The One and Only (Waylon Jennings album), The One and Only (disambiguation), The One and Only (song), The One and Only: Wikipedia, the Free Encyclopedia
  9. one and only: FreeDictionary.org
  10. one and only: Mnemonic Dictionary
  11. one and only: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. one and only: Encyclopedia

Slang (1 matching dictionary)
  1. The One and only: Urban Dictionary

Definitions from Wiktionary (one and only)

adjective:  (idiomatic) Unique, one of a kind.
noun:  (idiomatic) Only love, sole sweetheart.
noun:  The most talented or famous person (within in a specific context)

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