Usually means: Use of drug for unapproved indications.
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We found 14 dictionaries that define the word off label:

General (9 matching dictionaries)
  1. off-label: Merriam-Webster
  2. off-label: Oxford Learner's Dictionaries
  3. off-label: American Heritage Dictionary of the English Language
  4. off label: Collins English Dictionary
  5. Off-Label, Off-label, off-label: Wordnik
  6. off-label, off label: Wiktionary
  7. off-label, off label: Dictionary.com
  8. Off-label, Off label: Wikipedia, the Free Encyclopedia
  9. off-label: TheFreeDictionary.com

Medicine (5 matching dictionaries)
  1. online medical dictionary (No longer online)
  2. AIDS Medical Glossary and Drug Chart (No longer online)
  3. off-label: Dictionary of Cancer Terms
  4. Glossary of HIV/AIDS Related Terms (No longer online)
  5. Off-label, Off label: Medical dictionary

Definitions from Wiktionary (off label)

adjective:  (medicine, of a prescription medication) Outside of regulatorily approved indications, but (unless otherwise specified) within the bounds of reasonable use as defined by a licensed prescriber.
adverb:  (medicine, of a prescription medication) Outside of regulatorily approved indications, but (unless otherwise specified) within the bounds of reasonable use as defined by a licensed prescriber.

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