Usually means: Started and progressing successfully, quickly.
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We found 3 dictionaries that define the word off and running:

General (2 matching dictionaries)
  1. off and running: Wiktionary
  2. Off and Running: Wikipedia, the Free Encyclopedia

Miscellaneous (1 matching dictionary)
  1. off and running: Idioms

Definitions from Wiktionary (off and running)

adjective:  (idiomatic) Launched or launching vigorously into a course of action.

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