Sorry, no online dictionaries contain the exact phrase noxious substance.
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Reverse dictionary results:
1. toxin
2. poison
3. contaminant
4. pollutant
5. hazardous material
6. contamination
7. desiccated
8. exsiccative
9. cauterization
10. desiccant
11. etiolated
12. depletion
13. desiccation
14. exsiccant
15. dried
16. vaporousness
17. desiccate
18. siccative
19. desiccative
20. discolored
21. infrigidation
22. siccation
23. cold pack
24. cold short
25. dehydrate
26. frigorific
27. palen
28. adust
29. caustic
30. escharotic
31. excrementitious
32. refrigerium
33. antiperspirant
34. ashen
35. empale
36. exsiccate
37. exsiccation
38. malaria
39. blacken
40. blackening

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You can look up the words in the phrase individually using these links:   noxious ?   substance ?
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noxi*to search for words beginning with noxi, or
*anceto search for words ending with ance
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