Usually means: Above all else; of greatest importance.
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We found 6 dictionaries that define the word most importantly:

General (6 matching dictionaries)
  1. most importantly: Vocabulary.com
  2. most importantly: Dictionary.com
  3. most importantly: Rhymezone
  4. most importantly: FreeDictionary.org
  5. most importantly: Mnemonic Dictionary
  6. most importantly: TheFreeDictionary.com

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Definitions from WordNet (most importantly)

▸ adverb:  above and beyond all other consideration
▸ adverb:  of greatest importance


Opposite:
least importantly, insignificantly, trivially

Types:
crucial, essential, key, vital, more...

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Similar:

Opposite:
least importantly, insignificantly, trivially

Types:
crucial, essential, key, vital, more...




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