Usually means: Constantly unhappy, negative, and pessimistic.
Definitions Related words Mentions
We found 9 dictionaries that define the word misery guts:

General (7 matching dictionaries)
  1. misery guts: Merriam-Webster
  2. misery guts: Collins English Dictionary
  3. misery guts: Cambridge Advanced Learner's Dictionary
  4. Misery Guts: Wikipedia, the Free Encyclopedia
  5. misery-guts: TheFreeDictionary.com
  6. misery guts: Wiktionary

Slang (2 matching dictionaries)
  1. misery-guts: English slang and colloquialisms used in the United Kingdom
  2. misery guts: Urban Dictionary

Definitions from Wiktionary (Misery guts)

noun:  Alternative form of miseryguts [(colloquial) A miserable, negative person.]

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