Might mean (unverified): Issue or matter needing resolution.
Definitions Related words Mentions
We found one dictionary that defines the word mesele:

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  1. mesele: Wiktionary

Definitions from Wiktionary (Mesele)

adjective:  Obsolete form of mesel in its various senses. [(medicine, obsolete) Synonym of leprous: having leprosy or a similar skin disorder.]
noun:  Obsolete form of mesel in its various senses. [(medicine, obsolete) Synonym of leper.]

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