Usually means: Slang term for MDMA pills.
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We found 3 dictionaries that define the word mandies:

General (1 matching dictionary)
  1. Mandies, mandies: Wiktionary

Medicine (1 matching dictionary)
  1. Mandies: Medical dictionary

Slang (1 matching dictionary)
  1. mandies: Urban Dictionary

Definitions from Wiktionary (mandies)

noun:  (slang) The drug methaqualone, used recreationally.

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