Usually means: Create significance or success from.
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We found 6 dictionaries that define the word make something of:

General (5 matching dictionaries)
  1. make something of, make something of (oneself): Merriam-Webster
  2. make something of: Oxford Learner's Dictionaries
  3. make something of: Wiktionary
  4. make something of: Dictionary.com
  5. make something of: TheFreeDictionary.com

Miscellaneous (1 matching dictionary)
  1. make something of: Idioms

Definitions from Wiktionary (make something of)

verb:  To transform (an object or person) into something worthwhile.
verb:  To develop an understanding or interpretation of.
verb:  To insist on or emphatically challenge (a point or topic, especially one which may be a subject of disagreement).

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