Usually means: Persistent, severe depression impacting functioning.
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We found 12 dictionaries that define the word major depressive disorder:

General (5 matching dictionaries)
  1. major depressive disorder: Merriam-Webster
  2. major depressive disorder: Dictionary.com
  3. Major Depressive Disorder, Major depressive disorder: Wikipedia, the Free Encyclopedia
  4. Major Depressive Disorder: TheFreeDictionary.com
  5. major depressive disorder: Wiktionary

Business (1 matching dictionary)
  1. Major Depressive Disorder: Legal dictionary

Computing (1 matching dictionary)
  1. Major Depressive Disorder: Encyclopedia

Medicine (5 matching dictionaries)
  1. major depressive disorder: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. Medical Dictionary (No longer online)
  4. major depressive disorder: Medical dictionary
  5. University of Maryland Glossary of Medical Terms (No longer online)

Definitions from Wiktionary (major depressive disorder)

noun:  (psychiatry) A mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.

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