Usually means: Primary focus or central element.
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We found 7 dictionaries that define the word main thing:

General (4 matching dictionaries)
  1. main thing: Wiktionary
  2. The Main Thing (Real Estate album), The Main Thing: Wikipedia, the Free Encyclopedia

Business (1 matching dictionary)
  1. main thing: Legal dictionary

Miscellaneous (2 matching dictionaries)
  1. Navajo Code Talkers' Dictionary (No longer online)
  2. AbbreviationZ (No longer online)

Definitions from Wiktionary (main thing)

noun:  The most important factor; the principle consideration.

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