Usually means: Primary route or course taken.
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We found 24 dictionaries that define the word main line:

General (20 matching dictionaries)
  1. main line: Longman Dictionary of Contemporary English
  2. main line: Merriam-Webster
  3. Main Line, Main Line, main line: Oxford Learner's Dictionaries
  4. Main Line, main line: American Heritage Dictionary of the English Language
  5. main-line, main line: Collins English Dictionary
  6. main line: Vocabulary.com
  7. main-line, main line: Wordnik
  8. main line: Cambridge Advanced Learner's Dictionary
  9. Main line: InfoVisual Visual Dictionary
  10. main line: Wiktionary
  11. main line: Infoplease Dictionary
  12. main-line, main line: Dictionary.com
  13. Main Line: Online Etymology Dictionary
  14. Main Line (Columbus to Chicago), Main Line (LIRR), Main Line (Long Island Rail Road), Main Line (Long Island Railroad), Main Line (NJ Transit), Main Line (Pennsylvania), Main Line (Pennsylvania Railroad), Main Line (Pittsburgh to St. Louis), Main Line (Sri Lanka), Main Line (disambiguation), Main Line, Main line (political), Main line (railway): Wikipedia, the Free Encyclopedia
  15. main line: Rhymezone
  16. main line: FreeDictionary.org
  17. main line: Mnemonic Dictionary
  18. Main Line, main-line: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. Main-line, main line: Encyclopedia

Medicine (2 matching dictionaries)
  1. main line: Merriam-Webster Medical Dictionary
  2. Main-line, main line: Medical dictionary

Slang (1 matching dictionary)
  1. Main Line: Urban Dictionary

(Note: See main_lines as well.)

Definitions from Wiktionary (main line)

noun:  (chess) A standard sequence of opening moves considered to be best play.
noun:  Alternative form of mainline [(aviation) An airline's main operating unit, as opposed to codeshares or regional subsidiaries.]
adjective:  (chess) Alternative form of mainline [Normal, principal or standard.]

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