Usually means: Opportunity for significant personal gain.
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We found 12 dictionaries that define the word main chance:

General (12 matching dictionaries)
  1. main chance: Merriam-Webster
  2. main chance: American Heritage Dictionary of the English Language
  3. the main chance: Collins English Dictionary
  4. main chance, the main chance: Wordnik
  5. main chance: Wiktionary
  6. main chance: Infoplease Dictionary
  7. Main chance, The main chance, main chance: Dictionary.com
  8. The Main Chance: Wikipedia, the Free Encyclopedia
  9. Main Chance: Dictionary of Phrase and Fable (1898)
  10. main chance, the main chance: FreeDictionary.org
  11. The main chance, main chance: TheFreeDictionary.com
  12. Main chance: Phrase Finder

Definitions from Wiktionary (main chance)

noun:  (obsolete) A venture which stands the best likelihood of success; a risk; fortune (of a person, country etc.).
noun:  One's primary interest in life; livelihood, especially an opportunity to benefit oneself.

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