Usually means: Aggressive, uncontrolled, rabid canine behavior.
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We found 13 dictionaries that define the word mad dog:

General (6 matching dictionaries)
  1. mad-dog: Wordnik
  2. mad-dog, mad dog: Wiktionary
  3. mad-dog: Infoplease Dictionary
  4. mad-dog, mad dog: Dictionary.com
  5. Mad Dog (DC Comics), Mad Dog (Marvel Comics), Mad Dog (TV series), Mad Dog (album), Mad Dog (comics), Mad Dog (disambiguation), Mad Dog (oil platform), Mad Dog: Wikipedia, the Free Encyclopedia
  6. Mad dog: Wikipedia, the Free Encyclopedia

Medicine (1 matching dictionary)
  1. mad dog: Medical dictionary

Miscellaneous (2 matching dictionaries)
  1. Brilliant Dream Dictionary (No longer online)
  2. AbbreviationZ (No longer online)

Slang (4 matching dictionaries)
  1. mad dog, mad dog: Green’s Dictionary of Slang
  2. Mad dog: Street Terms: Drugs and the Drug Trade
  3. The Mad Dog: Urban Dictionary
  4. American-Australian Slang Dictionary (No longer online)

Definitions from Wiktionary (mad dog)

noun:  A rabid dog.
noun:  (figuratively, by extension) Someone who is aggressive and fanatical; an aggressor who cannot be reasoned with.
noun:  (aviation) A McDonnell Douglas MD-80 series aircraft.

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