Usually means: Release or relax; lessen control.
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We found 8 dictionaries that define the word loose off:

General (7 matching dictionaries)
  1. loose off: Vocabulary.com
  2. loose off: Wiktionary
  3. loose off: Dictionary.com
  4. loose off: Rhymezone
  5. loose off: FreeDictionary.org
  6. loose off: Mnemonic Dictionary
  7. loose off: TheFreeDictionary.com

Slang (1 matching dictionary)
  1. Loose-Off: Urban Dictionary

Definitions from Wiktionary (loose off)

verb:  (ambitransitive, informal) to fire (a weapon, or ammunition); to shoot (using a firearm)
verb:  (transitive, archaic) to unfasten, to loosen (chains, bonds, etc.)

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