Might mean (unverified): Abnormal softening of brain tissue.
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We found 2 dictionaries that define the word leptoma:

General (1 matching dictionary)
  1. leptoma: Wiktionary

Science (1 matching dictionary)
  1. Bryological (No longer online)

Definitions from Wiktionary (leptoma)

noun:  (palynology) A thin-walled area on a pollen grain

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