Might mean (unverified): Final factor causing inevitable failure.
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We found one dictionary that defines the word last nail in the coffin:

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  1. last nail in the coffin: Wiktionary

Definitions from Wiktionary (Last nail in the coffin)

noun:  (idiomatic) Alternative form of final nail in the coffin [(idiomatic) Something that is ultimately responsible for a previously prospective demise or failure.]

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