Usually means: Lacking sense, foolish, or stubborn.
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We found 7 dictionaries that define the word knuckleheaded:

General (6 matching dictionaries)
  1. knuckleheaded: Merriam-Webster
  2. knuckleheaded: Collins English Dictionary
  3. knuckleheaded: Wordnik
  4. knuckleheaded: Wiktionary
  5. knuckleheaded: Dictionary.com
  6. knuckleheaded: TheFreeDictionary.com

Slang (1 matching dictionary)
  1. knuckleheaded: Green’s Dictionary of Slang

(Note: See knucklehead as well.)

Definitions from Wiktionary (knuckleheaded)

adjective:  Stupid or inept, like a knucklehead.

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