Usually means: Go ahead, exert yourself fully.
Definitions Related words Mentions
We found 5 dictionaries that define the word knock oneself out:

General (4 matching dictionaries)
  1. knock oneself out: Merriam-Webster
  2. knock oneself out, knock oneself out: Oxford Learner's Dictionaries
  3. knock oneself out: Wiktionary
  4. knock oneself out: Phrasal Verb Page

Miscellaneous (1 matching dictionary)
  1. knock oneself out: Idioms

Definitions from Wiktionary (knock oneself out)

verb:  (idiomatic, informal) To go ahead; to do as one pleases; to enjoy oneself; to endeavor very hard at a task.

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