Usually means: Excited or nervous, highly strung.
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We found 13 dictionaries that define the word keyed up:

General (11 matching dictionaries)
  1. keyed up: Merriam-Webster
  2. keyed up: Collins English Dictionary
  3. Keyed-Up, keyed-up: Wordnik
  4. keyed up: Cambridge Advanced Learner's Dictionary
  5. keyed up: Wiktionary
  6. keyed up: Dictionary.com
  7. Keyed Up: Wikipedia, the Free Encyclopedia
  8. keyed up: TheFreeDictionary.com
  9. keyed up: Longman Dictionary of Contemporary English

Miscellaneous (1 matching dictionary)
  1. keyed up: Idioms

Slang (1 matching dictionary)
  1. Key'ed Up, keyed up: Urban Dictionary

Definitions from Wiktionary (keyed up)

adjective:  (colloquial) Nervous; worried.

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