Usually means: Excessive thickening of the skin.
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We found 9 dictionaries that define the word hyperkeratotic:

General (6 matching dictionaries)
  1. hyperkeratotic: Merriam-Webster
  2. hyperkeratotic: Collins English Dictionary
  3. hyperkeratotic: Wiktionary
  4. hyperkeratotic: Dictionary.com
  5. Hyperkeratotic: Wikipedia, the Free Encyclopedia
  6. hyperkeratotic: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. hyperkeratotic: Encyclopedia

Medicine (2 matching dictionaries)
  1. hyperkeratotic: Merriam-Webster Medical Dictionary
  2. hyperkeratotic: Medical dictionary

(Note: See hyperkeratosis as well.)

Definitions from Wiktionary (hyperkeratotic)

adjective:  Of, pertaining to, or suffering from hyperkeratosis

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