Usually means: Persistently high disease prevalence area.
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We found 6 dictionaries that define the word hyperendemic:

General (4 matching dictionaries)
  1. hyperendemic: Merriam-Webster
  2. hyperendemic: Collins English Dictionary
  3. hyperendemic: Wiktionary
  4. hyperendemic: Dictionary.com

Medicine (2 matching dictionaries)
  1. hyperendemic: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)

Definitions from Wiktionary (hyperendemic)

adjective:  (medicine) That has a high and continued incidence in an area

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