Usually means: Area with high infection risk.
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We found 5 dictionaries that define the word hot zone:

General (5 matching dictionaries)
  1. hot zone: Collins English Dictionary
  2. hot-zone: Wordnik
  3. hot zone: Wiktionary
  4. Hot Zone (Stargate Atlantis), Hot zone (disambiguation), Hot zone (environment), Hot zone, The Hot Zone (TV series), The Hot Zone (U.S. TV series), The Hot Zone (miniseries), The Hot Zone: Wikipedia, the Free Encyclopedia
  5. hot zone: TheFreeDictionary.com

Definitions from Wiktionary (hot zone)

noun:  (firefighting) An area to which access is restricted because it is contaminated with radiation or a chemical or biological biohazard.
noun:  An area where fighting or hostilities are likely to erupt.
noun:  An apparatus for growing crystals at very hot temperatures.
noun:  Used other than figuratively or idiomatically: see hot, zone.

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