Might mean (unverified): Powerful sedative, often metaphorically used.
Definitions Related words Mentions
We found 2 dictionaries that define the word horse tranquilizer:

General (1 matching dictionary)
  1. horse tranquilizer: Wiktionary

Slang (1 matching dictionary)
  1. Horse tranquilizer: Street Terms: Drugs and the Drug Trade

Definitions from Wiktionary (horse tranquilizer)

noun:  (slang) The drug phencyclidine (PCP).
noun:  (slang) Ketamine.
noun:  Used other than figuratively or idiomatically: see horse, tranquilizer.

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