Usually means: Disease constantly prevalent in population.
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We found 7 dictionaries that define the word holoendemic:

General (3 matching dictionaries)
  1. holoendemic: Wiktionary
  2. holoendemic: Dictionary.com
  3. Holoendemic: Wikipedia, the Free Encyclopedia

Medicine (4 matching dictionaries)
  1. holoendemic: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. online medical dictionary (No longer online)
  4. holoendemic: Medical dictionary

Definitions from Wiktionary (holoendemic)

adjective:  (medicine) endemic in the whole population of a given region

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