Usually means: Enzymes that remove acetyl from histones.
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We found 5 dictionaries that define the word histone deacetylase:

General (2 matching dictionaries)
  1. histone deacetylase: Wiktionary
  2. Histone deacetylase: Wikipedia, the Free Encyclopedia

Medicine (3 matching dictionaries)
  1. histone deacetylase: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)
  3. histone deacetylase: Dictionary of Cancer Terms

Definitions from Wiktionary (histone deacetylase)

noun:  (biochemistry) Any of a class of enzymes that remove acetyl groups from lysine amino acids in proteins, especially the histone proteins of the nucleus

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