Definitions from Wiktionary (hightail it)
▸ verb: (informal, chiefly Canada, US) To hurry or run; often, to flee.
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▸ verb: (informal, chiefly Canada, US) To hurry or run; often, to flee.
Similar:
hightail,
take to one's heels,
do a runner,
hotfoot it,
highball,
run for the hills,
skedaddle,
run for it,
hump it,
fly off,
more...
Opposite:
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▸ Invented words related to hightail it