Usually means: Person with unstable or eccentric behavior.
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We found 12 dictionaries that define the word headcase:

General (9 matching dictionaries)
  1. headcase: Collins English Dictionary
  2. headcase: Wordnik
  3. headcase: Cambridge Advanced Learner's Dictionary
  4. headcase: Wiktionary
  5. headcase: Dictionary.com
  6. headcase: TheFreeDictionary.com
  7. headcase: Longman Dictionary of Contemporary English

Slang (3 matching dictionaries)
  1. headcase: Green’s Dictionary of Slang
  2. headcase: English slang and colloquialisms used in the United Kingdom
  3. headcase: Urban Dictionary

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  (informal, derogatory, countable) A mentally unbalanced, unpredictable person, especially one who displays aggressive behavior.
noun:  (genetics, uncountable) A genetic sequence that inhibits terminal branching of the trachea and regulates dendrite pruning.

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