Might mean (unverified): Large meal causing extreme fullness.
Definitions Related words Mentions
We found 2 dictionaries that define the word gutbuster:

General (1 matching dictionary)
  1. gutbuster: Wiktionary

Slang (1 matching dictionary)
  1. Gutbuster: Urban Dictionary

Definitions from Wiktionary (gutbuster)

noun:  (informal) Something very funny.

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