Sorry, no online dictionaries contain the exact phrase go against grain.
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Reverse dictionary results:
1. oppose
 2. contradict
3. defy
4. disagree
5. rebuke
6. controvert
7. gainsay
8. negate
9. oppugn
10. debunk
 11. disaffirm
12. disconfirm
13. disprove
14. improve
15. infirm
16. objection
17. refel
18. contestation
19. contrectation
20. deconflict
 21. defence
22. defensative
23. defense mechanism
24. defensive
25. demurrer
26. denay
27. disallow
28. disbelieve
29. invalidate
30. negative
 31. negative pregnant
32. no
33. nope
34. nyet
35. rebuff
36. rebuffing
37. rebut
38. red light

You can look up the words in the phrase individually using these links:   go ?   against ?   grain ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
go a*to search for words beginning with go a, or
*rainto search for words ending with rain
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