Usually means: Cease, surrender, or stop something.
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We found 6 dictionaries that define the word give it up:

General (4 matching dictionaries)
  1. give it up: Oxford Learner's Dictionaries
  2. give it up: Wiktionary
  3. give it up: Dictionary.com
  4. Give It Up (Bonnie Raitt album), Give It Up (Hothouse Flowers song), Give It Up (KC song), Give It Up (LCD Soundsystem song), Give It Up (Public Enemy song), Give It Up (The Good Men song), Give It Up (Twista song), Give It Up (Victorious song), Give It Up (Wilson Phillips song), Give It Up (ZZ Top song), Give It Up, Give it up: Wikipedia, the Free Encyclopedia

Slang (2 matching dictionaries)
  1. give it up: Green’s Dictionary of Slang
  2. give it up: English slang and colloquialisms used in the United Kingdom

Definitions from Wiktionary (give it up)

verb:  (usually followed by for) To welcome onto a stage by cheering or applauding.
verb:  (euphemistic) To agree to sexual intercourse, especially if reluctantly.
verb:  (intransitive, slang) To hand over or relinquish; to explain something or tell a secret.

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