Definitions from Wiktionary (give it a rest)
▸ verb: (colloquial) Stop doing that; stop nagging, complaining, or otherwise being a nuisance.
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▸ verb: (colloquial) Stop doing that; stop nagging, complaining, or otherwise being a nuisance.
Similar:
knock it off,
give someone a break,
get off someone's case,
leave alone,
get off someone's back,
hear the end of it,
shut up,
put the brakes on,
rest,
leave it at that,
more...
Opposite:
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▸ Wikipedia articles (New!)
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▸ Rhymes of give it a rest
▸ Invented words related to give it a rest