Usually means: Progressive neurological decline from syphilis.
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We found 7 dictionaries that define the word general paralysis:

General (3 matching dictionaries)
  1. general paralysis: Wiktionary
  2. general paralysis: Infoplease Dictionary
  3. general paralysis: Dictionary.com

Business (1 matching dictionary)
  1. General paralysis: Legal dictionary

Computing (1 matching dictionary)
  1. general paralysis: Encyclopedia

Medicine (2 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. General paralysis: Medical dictionary

Definitions from Wiktionary (general paralysis)

noun:  Synonym of general paresis of the insane

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