Usually means: Substance initiating use of harder drugs.
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We found 17 dictionaries that define the word gateway drug:

General (14 matching dictionaries)
  1. gateway drug: Merriam-Webster
  2. gateway drug: Oxford Learner's Dictionaries
  3. gateway drug: American Heritage Dictionary of the English Language
  4. gateway drug: Collins English Dictionary
  5. gateway drug: Vocabulary.com
  6. gateway drug: Wiktionary
  7. gateway drug: Infoplease Dictionary
  8. gateway drug: Dictionary.com
  9. Gateway Drug (song), Gateway drug: Wikipedia, the Free Encyclopedia
  10. gateway drug: Rhymezone
  11. gateway drug: FreeDictionary.org
  12. gateway drug: Mnemonic Dictionary
  13. gateway drug: TheFreeDictionary.com
  14. gateway drug: Longman Dictionary of Contemporary English

Medicine (2 matching dictionaries)
  1. gateway drug: Merriam-Webster Medical Dictionary
  2. gateway drug: Medical dictionary

Slang (1 matching dictionary)
  1. gateway drug: Urban Dictionary

(Note: See gateway_drugs as well.)

Definitions from Wiktionary (gateway drug)

noun:  An addictive substance that is seen as relatively harmless by itself, but is believed to encourage the user to experiment with more harmful substances.
noun:  (by extension, figurative) Any thing or area of interest that tends to lead to deeper involvement.

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