Usually means: Dissolves in fats, not water.
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We found 15 dictionaries that define the word fat-soluble:

General (12 matching dictionaries)
  1. fat-soluble: American Heritage Dictionary of the English Language
  2. fat-soluble, fat-soluble: Collins English Dictionary
  3. fat-soluble: Vocabulary.com
  4. fat-soluble: Wordnik
  5. fat-soluble: Wiktionary
  6. fat-soluble: Webster's New World College Dictionary, 4th Ed.
  7. fat-soluble: Infoplease Dictionary
  8. fat-soluble: Dictionary.com
  9. Fat-soluble: Wikipedia, the Free Encyclopedia
  10. fat-soluble: FreeDictionary.org
  11. fat-soluble: Mnemonic Dictionary
  12. fat-soluble: TheFreeDictionary.com

Medicine (3 matching dictionaries)
  1. fat-soluble: Merriam-Webster Medical Dictionary
  2. fat-soluble: Medical dictionary
  3. Hyperdictionary (No longer online)

Definitions from Wiktionary (fat-soluble)

adjective:  Soluble in lipids, and in organic solvents.
adjective:  that tends to accumulate in the adipose tissue of the body

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