Usually means: Enzyme that excises damaged DNA.
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We found 3 dictionaries that define the word excinuclease:

General (2 matching dictionaries)
  1. excinuclease: Wiktionary
  2. Excinuclease: Wikipedia, the Free Encyclopedia

Science (1 matching dictionary)
  1. Drug Discovery and Development (No longer online)

Definitions from Wiktionary (excinuclease)

noun:  (genetics, biochemistry) A nuclease that carries out excision as part of DNA repair

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