Usually means: Beat or thrash someone severely.
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We found 8 dictionaries that define the word duff up:

General (5 matching dictionaries)
  1. duff up: Collins English Dictionary
  2. duff up: Wiktionary
  3. duff up: TheFreeDictionary.com
  4. duff up: Longman Dictionary of Contemporary English

Slang (3 matching dictionaries)
  1. duff up: Green’s Dictionary of Slang
  2. duff up: English slang and colloquialisms used in the United Kingdom
  3. duff up: Urban Dictionary

Definitions from Wiktionary (duff up)

verb:  (UK, transitive, slang) To beat up, to give a beating to.

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