Usually means: Preferred medication for specific condition.
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We found 4 dictionaries that define the word drug of choice:

General (3 matching dictionaries)
  1. drug of choice: Wiktionary
  2. drug of choice: Dictionary.com
  3. Drug of Choice: Wikipedia, the Free Encyclopedia

Medicine (1 matching dictionary)
  1. drug of choice: Medical dictionary

Definitions from Wiktionary (drug of choice)

noun:  (law, narcotics) The particular substance, usually illicit, to which a person is addicted.
noun:  (medicine, pharmacology) The best-choice medication designed to treat a particular medical problem.

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