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We found 3 dictionaries that define the word drain the main vein:

General (1 matching dictionary)
  1. drain the main vein: Wiktionary

Slang (2 matching dictionaries)
  1. drain the main vein: English slang and colloquialisms used in the United Kingdom
  2. Drain the main vein: Urban Dictionary

Definitions from Wiktionary (drain the main vein)

verb:  (vulgar slang, of men) To urinate.

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