Usually means: Decrease in cellular component activity.
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We found 11 dictionaries that define the word downregulation:

General (5 matching dictionaries)
  1. downregulation: Collins English Dictionary
  2. Downregulation, downregulation: Wordnik
  3. downregulation: Wiktionary
  4. downregulation: Dictionary.com
  5. Downregulation: Wikipedia, the Free Encyclopedia

Medicine (6 matching dictionaries)
  1. downregulation: Merriam-Webster Medical Dictionary
  2. Dorland's Illustrated Medical Dictionary (No longer online)
  3. Downregulation: MedTerms.com Medical Dictionary
  4. Glossary of HIV/AIDS Related Terms (No longer online)
  5. Downregulation: Medical dictionary
  6. Downregulation: Drug Medical Dictionary

Definitions from Wiktionary (downregulation)

noun:  (biology) The suppression of a response to a stimulus
noun:  (genetics) The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity

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