Usually means: Two substituents on one molecule.
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We found 7 dictionaries that define the word disubstituted:

General (7 matching dictionaries)
  1. disubstituted: Merriam-Webster
  2. disubstituted: Oxford Learner's Dictionaries
  3. disubstituted: Collins English Dictionary
  4. disubstituted: Wordnik
  5. disubstituted: Wiktionary
  6. disubstituted: Infoplease Dictionary
  7. disubstituted: Dictionary.com

Definitions from Wiktionary (disubstituted)

adjective:  (organic chemistry) Having two substituents

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