Usually means: Loss of purine bases from DNA.
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We found 5 dictionaries that define the word depurination:

General (3 matching dictionaries)
  1. depurination: Wiktionary
  2. depurination: Dictionary.com
  3. Depurination: Wikipedia, the Free Encyclopedia

Computing (1 matching dictionary)
  1. depurination: Encyclopedia

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Definitions from Wiktionary (depurination)

noun:  (biochemistry, genetics) The removal, by hydrolysis, of a purine base from DNA

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