Usually means: Enzyme that removes methyl group.
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We found 5 dictionaries that define the word demethylase:

General (4 matching dictionaries)
  1. demethylase: Wordnik
  2. demethylase: Wiktionary
  3. demethylase: Dictionary.com
  4. Demethylase: Wikipedia, the Free Encyclopedia

Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Definitions from Wiktionary (demethylase)

noun:  (biochemistry) Any enzyme that catalyzes the removal of a methyl group from a compound

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