Might mean (unverified): Burden or responsibility one accepts.
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We found one dictionary that defines the word cross to take up:

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  1. cross to take up: Wiktionary

Definitions from Wiktionary (Cross to take up)

noun:  (idiomatic) Alternative form of cross to bear [(idiomatic) A problem, or unpleasant or painful situation or person that one has to accept and deal with, although one finds it very difficult, or it causes trouble or worry over a long period of time.]

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