Usually means: Become friendly or ingratiate oneself.
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We found 6 dictionaries that define the word cotton up:

General (6 matching dictionaries)
  1. cotton up: Vocabulary.com
  2. cotton up: Dictionary.com
  3. cotton up: Rhymezone
  4. cotton up: FreeDictionary.org
  5. cotton up: Mnemonic Dictionary
  6. cotton up: TheFreeDictionary.com

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Definitions from WordNet (cotton up)

▸ verb:  ingratiate oneself to; often with insincere behavior


Opposite:
alienate, distance, disaffect, estranged, separate

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Opposite:
alienate, distance, disaffect, estranged, separate




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